Up to 5 cups of coffee per day may potentially lower heart disease risk, doctors sayDrinking up to five cups of coffee a day is safe for most adults, and regular coffee ... Inherited variations in a liver enzyme gene called CYP1A2 ...2026.07.22 Drinking up to five cups of coffee a day is safe for most adults, and regular coffee ... Inherited variations in a liver enzyme gene called CYP1A2 ...