Up to 5 cups of coffee per day may potentially lower heart disease risk, doctors say – WTOPUp to 5 cups of coffee per day may potentially lower heart disease risk, doctors say ... Inherited variations in a liver enzyme gene called CYP1A2 ...2026.07.22 Up to 5 cups of coffee per day may potentially lower heart disease risk, doctors say ... Inherited variations in a liver enzyme gene called CYP1A2 ...